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Assay Detail

CHEMBL5098709

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to CDK9 (unknown origin) assessed as dissociation constant by Surface Plasmon Resonance assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 9 (CHEMBL3116)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.
Barlaam B, De Savi C, Dishington A, Drew L, Ferguson AD, Ferguson D, Gu C, Hande S, Hassall L, Hawkins J, Hird AW, Holmes J, Lamb ML, Lister AS, McGuire TM, Moore JE, O'Connell N, Patel A, Pike KG, Sarkar U, Shao W, Stead D, Varnes JG, Vasbinder MM, Wang L, Wu L, Xue L, Yang B, Yao T.
J Med Chem (2021) 64 : 15189 -15213
PubMed 34647738 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 9.67 9.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5197170 1 9.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5197170 Kd = 0.213 nM 9.67