Assay Detail
Binding
CHEMBL5098727
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at N-terminal His-tagged wild type ML-IAP BIR domain (63 to 179 residues) (unknown origin) expressed in Escherichia coli BL21 using AVPIAQKSEK-biotinylated peptide as substrate incubated for 2 hrs by DELFIA assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 7 (CHEMBL1075127) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.92 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 8.05 |
| CHEMBL5186855 | — | — | 1 | 7.70 |
| CHEMBL5181541 | — | — | 1 | 7.46 |
| CHEMBL5174454 | — | — | 1 | 7.37 |
| CHEMBL5175233 | — | — | 1 | 7.30 |
| CHEMBL5195146 | — | — | 1 | 6.56 |
| CHEMBL5193194 | — | — | 1 | 6.55 |
| CHEMBL5191180 | — | — | 1 | 6.50 |
| CHEMBL5170823 | — | — | 1 | 6.32 |
| CHEMBL5203019 | — | — | 1 | 6.25 |
| CHEMBL5169527 | — | — | 1 | 6.06 |
| CHEMBL5200297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5186855 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5181541 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5174454 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5175233 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5195146 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL5193194 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5191180 | — | IC50 | = | 319.0 | nM | 6.50 |
| CHEMBL5170823 | — | IC50 | = | 482.0 | nM | 6.32 |
| CHEMBL5203019 | — | IC50 | = | 556.0 | nM | 6.25 |
| CHEMBL5169527 | — | IC50 | = | 866.0 | nM | 6.06 |
| CHEMBL5200297 | — | IC50 | > | 1000.0 | nM | - |