Assay Detail
Binding
CHEMBL5098730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at N-terminal His-tagged cIAP2-BIR3 domain (unknown origin) expressed in Escherichia coli BL21 using AVPIAQKSEK-biotinylated peptide as substrate incubated for 2 hrs by DELFIA assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 3 (CHEMBL5335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.73 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.77 |
| CHEMBL5174454 | — | — | 1 | 7.23 |
| CHEMBL5191180 | — | — | 1 | 6.85 |
| CHEMBL5170823 | — | — | 1 | 6.75 |
| CHEMBL5186855 | — | — | 1 | 6.62 |
| CHEMBL5175233 | — | — | 1 | 6.54 |
| CHEMBL5193194 | — | — | 1 | 6.43 |
| CHEMBL5195146 | — | — | 1 | 6.40 |
| CHEMBL5181541 | — | — | 1 | 6.37 |
| CHEMBL5203019 | — | — | 1 | 6.29 |
| CHEMBL5169527 | — | — | 1 | - |
| CHEMBL5200297 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5174454 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5191180 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5170823 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5186855 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5175233 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL5193194 | — | IC50 | = | 371.0 | nM | 6.43 |
| CHEMBL5195146 | — | IC50 | = | 397.0 | nM | 6.40 |
| CHEMBL5181541 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL5203019 | — | IC50 | = | 519.0 | nM | 6.29 |
| CHEMBL5169527 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL5200297 | — | IC50 | > | 1500.0 | nM | - |