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Assay Detail

CHEMBL5098795

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of beta-tubulin polymerization in human MCF7 cells using TMB as substrate incubated for 2 hrs by spectrophotometry analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type MCF7
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Tubulin beta (CHEMBL3832942)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.
Qiu X, Zhu L, Wang H, Tan Y, Yang Z, Yang L, Wan L.
Bioorg Med Chem (2021) 52 : 116510 -116510
PubMed 34826681 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.63 5.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5197309 1 5.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5197309 IC50 = 2320.0 nM 5.63