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Assay Detail

CHEMBL5099154

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to S1PR2 (unknown origin) assessed as dissociation constant by surface plasmon resonance analysis
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sphingosine 1-phosphate receptor 2 (CHEMBL2955)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Rational Design, Synthesis, and Biological Evaluation of Novel S1PR2 Antagonists for Reversing 5-FU-Resistance in Colorectal Cancer.
Luo D, Liu X, Jiang L, Guo Z, Lv Y, Tian X, Wang X, Cui S, Wan S, Qu X, Xu X, Li X.
J Med Chem (2022) 65 : 14553 -14577
PubMed 36269639 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 41 8.12 9.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5172220 1 9.31
CHEMBL5193759 1 9.20
CHEMBL5206290 1 9.16
CHEMBL5208524 1 9.14
CHEMBL5181599 1 9.06
CHEMBL5206026 1 9.05
CHEMBL3401388 1 9.01
CHEMBL5201190 1 8.94
CHEMBL3401386 1 8.38
CHEMBL5199565 1 8.29
CHEMBL3401387 1 8.18
CHEMBL5197668 1 8.14
CHEMBL5176095 1 8.13
CHEMBL5182489 1 8.06
CHEMBL5181338 1 8.03
CHEMBL5173580 1 7.90
CHEMBL4871603 1 7.88
CHEMBL5206287 1 7.67
CHEMBL5184083 1 7.53
CHEMBL3759434 1 7.50
CHEMBL5175095 1 7.46
CHEMBL5174563 1 7.25
CHEMBL5187883 1 7.17
CHEMBL5199950 1 7.05
CHEMBL5192337 1 7.03
CHEMBL3401383 1 6.70
CHEMBL5194262 1 -
CHEMBL5208236 1 -
CHEMBL5201537 1 -
CHEMBL5170245 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5172220 Kd = 0.49 nM 9.31
CHEMBL5193759 Kd = 0.63 nM 9.20
CHEMBL5206290 Kd = 0.69 nM 9.16
CHEMBL5208524 Kd = 0.73 nM 9.14
CHEMBL5181599 Kd = 0.88 nM 9.06
CHEMBL5206026 Kd = 0.89 nM 9.05
CHEMBL3401388 Kd = 0.98 nM 9.01
CHEMBL5201190 Kd = 1.15 nM 8.94
CHEMBL3401386 Kd = 4.15 nM 8.38
CHEMBL5199565 Kd = 5.16 nM 8.29
CHEMBL3401387 Kd = 6.62 nM 8.18
CHEMBL5197668 Kd = 7.23 nM 8.14
CHEMBL5176095 Kd = 7.48 nM 8.13
CHEMBL5182489 Kd = 8.76 nM 8.06
CHEMBL5181338 Kd = 9.44 nM 8.03
CHEMBL5173580 Kd = 12.65 nM 7.90
CHEMBL4871603 Kd = 13.2 nM 7.88
CHEMBL5206287 Kd = 21.54 nM 7.67
CHEMBL5184083 Kd = 29.21 nM 7.53
CHEMBL3759434 Kd = 31.6 nM 7.50
CHEMBL5175095 Kd = 34.8 nM 7.46
CHEMBL5174563 Kd = 55.62 nM 7.25
CHEMBL5187883 Kd = 66.92 nM 7.17
CHEMBL5199950 Kd = 88.5 nM 7.05
CHEMBL5192337 Kd = 94.34 nM 7.03
CHEMBL3401383 Kd = 198.22 nM 6.70
CHEMBL5207629 Kd > 1000.0 nM -
CHEMBL5197308 Kd > 1000.0 nM -
CHEMBL5175893 Kd > 1000.0 nM -
CHEMBL5172732 Kd > 1000.0 nM -
CHEMBL3401382 Kd > 1000.0 nM -
CHEMBL5195698 Kd > 1000.0 nM -
CHEMBL5185672 Kd > 1000.0 nM -
CHEMBL5177438 Kd > 1000.0 nM -
CHEMBL5197317 Kd > 1000.0 nM -
CHEMBL5204712 Kd > 1000.0 nM -
CHEMBL5202509 Kd > 1000.0 nM -
CHEMBL5170245 Kd > 1000.0 nM -
CHEMBL5201537 Kd > 1000.0 nM -
CHEMBL5208236 Kd > 1000.0 nM -
CHEMBL5194262 Kd > 1000.0 nM -