Assay Detail
Functional
CHEMBL5099175
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Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational Design, Synthesis, and Biological Evaluation of Novel S1PR2 Antagonists for Reversing 5-FU-Resistance in Colorectal Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.00 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 7.73 |
| CHEMBL3401388 | — | — | 1 | 4.26 |
| CHEMBL3759434 | — | — | 1 | - |
| CHEMBL5206026 | — | — | 1 | - |
| CHEMBL5193759 | — | — | 1 | - |
| CHEMBL5208524 | — | — | 1 | - |
| CHEMBL5181599 | — | — | 1 | - |
| CHEMBL5206290 | — | — | 1 | - |
| CHEMBL5172220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185 | FLUOROURACIL | IC50 | = | 18.77 | nM | 7.73 |
| CHEMBL3401388 | — | IC50 | = | 55360.0 | nM | 4.26 |
| CHEMBL3759434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5206026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5193759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5208524 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5181599 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5206290 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5172220 | — | IC50 | > | 100000.0 | nM | - |