Assay Detail
Functional
CHEMBL5099264
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Agonist activity at human adenosine A2B receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by LANCE ultra assay
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Structure-Activity Relationship Studies of Novel Adenosine A<sub>1</sub> Receptor-Selective Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.43 | 7.28 |
| pEC50 | 10 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | 4.0 | 1 | 7.28 |
| CHEMBL464859 | NECA | — | 1 | 7.20 |
| CHEMBL5195714 | — | — | 1 | 6.22 |
| CHEMBL5171042 | — | — | 1 | 6.04 |
| CHEMBL5174429 | — | — | 1 | 6.01 |
| CHEMBL5203632 | — | — | 1 | 5.37 |
| CHEMBL5208245 | — | — | 1 | 5.36 |
| CHEMBL5197358 | — | — | 1 | 5.31 |
| CHEMBL5205907 | — | — | 1 | 5.29 |
| CHEMBL5191989 | — | — | 1 | 5.10 |
| CHEMBL5187330 | — | — | 1 | 5.10 |
| CHEMBL5186757 | — | — | 1 | 4.90 |
| CHEMBL5188601 | — | — | 1 | 4.77 |
| CHEMBL5184828 | — | — | 1 | 4.72 |
| CHEMBL5174052 | — | — | 1 | 4.63 |
| CHEMBL5199871 | — | — | 1 | 4.57 |
| CHEMBL5170857 | — | — | 1 | 4.42 |
| CHEMBL5206687 | — | — | 1 | - |
| CHEMBL5171285 | — | — | 1 | - |
| CHEMBL5201013 | — | — | 1 | - |
| CHEMBL5172389 | — | — | 1 | - |
| CHEMBL5186981 | — | — | 1 | - |
| CHEMBL5209222 | — | — | 1 | - |
| CHEMBL5182056 | — | — | 1 | - |
| CHEMBL5179726 | — | — | 1 | - |
| CHEMBL5187478 | — | — | 1 | - |
| CHEMBL3771208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL477 | ADENOSINE | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL464859 | NECA | EC50 | = | 63.1 | nM | 7.20 |
| CHEMBL5195714 | — | EC50 | = | 602.56 | nM | 6.22 |
| CHEMBL5171042 | — | EC50 | = | 912.01 | nM | 6.04 |
| CHEMBL5174429 | — | EC50 | = | 977.24 | nM | 6.01 |
| CHEMBL5203632 | — | EC50 | = | 4265.8 | nM | 5.37 |
| CHEMBL5208245 | — | EC50 | = | 4365.16 | nM | 5.36 |
| CHEMBL5197358 | — | EC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL5205907 | — | EC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL5191989 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL5187330 | — | EC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL5186757 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL5188601 | — | EC50 | = | 16982.44 | nM | 4.77 |
| CHEMBL5184828 | — | EC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL5174052 | — | EC50 | = | 23442.29 | nM | 4.63 |
| CHEMBL5199871 | — | EC50 | = | 26915.35 | nM | 4.57 |
| CHEMBL5170857 | — | EC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL5206687 | — | pEC50 | - | — | - | |
| CHEMBL5171285 | — | pEC50 | - | — | - | |
| CHEMBL5201013 | — | pEC50 | - | — | - | |
| CHEMBL5172389 | — | pEC50 | - | — | - | |
| CHEMBL5186981 | — | pEC50 | - | — | - | |
| CHEMBL5209222 | — | pEC50 | - | — | - | |
| CHEMBL5182056 | — | pEC50 | - | — | - | |
| CHEMBL5179726 | — | pEC50 | - | — | - | |
| CHEMBL5187478 | — | pEC50 | - | — | - | |
| CHEMBL3771208 | — | pEC50 | - | — | - |