Assay Detail
Binding
CHEMBL5099291
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Inhibition of HDAC6 (unknown origin)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel pyrazinone derivatives as PI3K/HDAC dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.70 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5192159 | — | — | 1 | 8.38 |
| CHEMBL5201448 | — | — | 1 | 8.38 |
| CHEMBL5180796 | — | — | 1 | 8.35 |
| CHEMBL5184950 | — | — | 1 | 8.16 |
| CHEMBL5190763 | — | — | 1 | 8.13 |
| CHEMBL5180870 | — | — | 1 | 8.10 |
| CHEMBL5202725 | — | — | 1 | 8.04 |
| CHEMBL5191006 | — | — | 1 | 7.92 |
| CHEMBL5192044 | — | — | 1 | 7.89 |
| CHEMBL5174437 | — | — | 1 | 7.89 |
| CHEMBL5206969 | — | — | 1 | 7.85 |
| CHEMBL5175778 | — | — | 1 | 7.85 |
| CHEMBL5194733 | — | — | 1 | 7.82 |
| CHEMBL5204426 | — | — | 1 | 7.82 |
| CHEMBL5179687 | — | — | 1 | 7.82 |
| CHEMBL5172884 | — | — | 1 | 7.70 |
| CHEMBL5182660 | — | — | 1 | 7.68 |
| CHEMBL5170590 | — | — | 1 | 7.64 |
| CHEMBL5186022 | — | — | 1 | 7.52 |
| CHEMBL5171575 | — | — | 1 | 7.50 |
| CHEMBL5202781 | — | — | 1 | 7.46 |
| CHEMBL5187051 | — | — | 1 | 7.27 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.15 |
| CHEMBL5183646 | — | — | 1 | 6.96 |
| CHEMBL5185319 | — | — | 1 | 6.71 |
| CHEMBL5172866 | — | — | 1 | 6.19 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5192159 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5201448 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5180796 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL5184950 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5190763 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5180870 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL5202725 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL5191006 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5192044 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5174437 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5206969 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5175778 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5194733 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5204426 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5179687 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5172884 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5182660 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5170590 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5186022 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5171575 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL5202781 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5187051 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5183646 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5185319 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL5172866 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2017974 | BUPARLISIB | IC50 | - | — | - |