Assay Detail
Functional
CHEMBL5099294
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Antiproliferative activity against human K562 cells assessed as inhibition of cell proliferation incubated for 72 hrs by CCK8 assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel pyrazinone derivatives as PI3K/HDAC dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.72 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5180796 | — | — | 1 | 6.92 |
| CHEMBL5206969 | — | — | 1 | 6.23 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.14 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.93 |
| CHEMBL5187051 | — | — | 1 | 5.42 |
| CHEMBL5170590 | — | — | 1 | 5.42 |
| CHEMBL5185319 | — | — | 1 | 5.34 |
| CHEMBL5202725 | — | — | 1 | 5.21 |
| CHEMBL5179687 | — | — | 1 | 4.86 |
| CHEMBL5183646 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5180796 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5206969 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5187051 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5170590 | — | IC50 | = | 3840.0 | nM | 5.42 |
| CHEMBL5185319 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL5202725 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL5179687 | — | IC50 | = | 13850.0 | nM | 4.86 |
| CHEMBL5183646 | — | IC50 | > | 50000.0 | nM | - |