Assay Detail
Functional
CHEMBL5099378
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Anti-proliferative activity against human BXPC-3 cells assessed as cell growth inhibition incubated for 72 hrs by MTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 8.40 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5177956 | — | — | 1 | 9.40 |
| CHEMBL5200170 | — | — | 1 | 8.89 |
| CHEMBL5209107 | — | — | 1 | 8.85 |
| CHEMBL5171007 | — | — | 1 | 8.82 |
| CHEMBL5201151 | — | — | 1 | 8.77 |
| CHEMBL5208945 | — | — | 1 | 8.72 |
| CHEMBL5209399 | — | — | 1 | 8.72 |
| CHEMBL5189135 | — | — | 1 | 8.57 |
| CHEMBL5178622 | — | — | 1 | 8.48 |
| CHEMBL5201419 | — | — | 1 | 8.32 |
| CHEMBL5205645 | — | — | 1 | 7.94 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 5.28 |
| CHEMBL5193538 | — | — | 1 | - |
| CHEMBL5201252 | — | — | 1 | - |
| CHEMBL5184385 | — | — | 1 | - |
| CHEMBL5175035 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5177956 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL5200170 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5209107 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5171007 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5201151 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5208945 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5209399 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5189135 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5178622 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL5201419 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5205645 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 5306.0 | nM | 5.28 |
| CHEMBL5193538 | — | IC50 | - | — | - | |
| CHEMBL5201252 | — | IC50 | - | — | - | |
| CHEMBL5184385 | — | IC50 | - | — | - | |
| CHEMBL5175035 | — | IC50 | - | — | - |