Assay Detail
Functional
CHEMBL5099501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-necroptotic activity in TSZ induced human HT-29 cells assessed as increase in cell viability pretreated with compound followed by TSZ stimulation and measured after 16 hrs by celltiter-glo luminescent cell viability assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5172295 | — | — | 1 | 8.70 |
| CHEMBL4071864 | GSK2982772 | 2.0 | 1 | 8.44 |
| CHEMBL5185667 | — | — | 1 | 8.10 |
| CHEMBL5173571 | — | — | 1 | 8.00 |
| CHEMBL5189581 | — | — | 1 | 8.00 |
| CHEMBL5179151 | — | — | 1 | 7.92 |
| CHEMBL5171828 | — | — | 1 | 7.89 |
| CHEMBL5189681 | — | — | 1 | 7.09 |
| CHEMBL5205822 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5172295 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4071864 | GSK2982772 | EC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5185667 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5173571 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5189581 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5179151 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5171828 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5189681 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5205822 | — | EC50 | = | 170.0 | nM | 6.77 |