Assay Detail
Binding
CHEMBL5099649
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Binding affinity to wild type TTR (unknown origin) assessed as dissociation constant by ITC assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 7.39 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5203058 | — | — | 1 | 8.21 |
| CHEMBL5172990 | — | — | 1 | 7.58 |
| CHEMBL5172066 | — | — | 1 | 7.51 |
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | 7.47 |
| CHEMBL5205412 | — | — | 1 | 7.07 |
| CHEMBL5183147 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5203058 | — | Kd | = | 6.2 | nM | 8.21 |
| CHEMBL5172990 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL5172066 | — | Kd | = | 31.0 | nM | 7.51 |
| CHEMBL1324 | TOLCAPONE | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL5205412 | — | Kd | = | 85.0 | nM | 7.07 |
| CHEMBL5183147 | — | Kd | = | 310.0 | nM | 6.51 |