Assay Detail
Binding
CHEMBL5099650
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Binding affinity to wild type TTR (unknown origin) assessed as gibbs free energy change by ITC analysis
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| deltaG | 5 | - | - |
| Kd | 1 | 7.47 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | 4.0 | 1 | 7.47 |
| CHEMBL5183147 | — | — | 1 | - |
| CHEMBL5172066 | — | — | 1 | - |
| CHEMBL5205412 | — | — | 1 | - |
| CHEMBL5172990 | — | — | 1 | - |
| CHEMBL5203058 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1324 | TOLCAPONE | Kd | = | 34.0 | nM | 7.47 |
| CHEMBL5183147 | — | deltaG | = | -8.9 | kcal/mol | - |
| CHEMBL5172066 | — | deltaG | = | -10.3 | kcal/mol | - |
| CHEMBL5205412 | — | deltaG | = | -10.2 | kcal/mol | - |
| CHEMBL5172990 | — | deltaG | = | -10.4 | kcal/mol | - |
| CHEMBL5203058 | — | deltaG | = | -11.2 | kcal/mol | - |