Assay Detail
Binding
CHEMBL5100439
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-N-methylspiperone from human D3 receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Studies of 1<i>H</i>-Imidazo[4,5-<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.49 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195535 | — | — | 1 | 6.07 |
| CHEMBL5192606 | — | — | 1 | 5.28 |
| CHEMBL5170354 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195535 | — | Ki | = | 846.0 | nM | 6.07 |
| CHEMBL5192606 | — | Ki | = | 5280.0 | nM | 5.28 |
| CHEMBL5170354 | — | Ki | = | 7630.0 | nM | 5.12 |