Assay Detail
Binding
CHEMBL5100443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TPSO receptor expressed in human HEK293T cell membrane incubated for 90 mins by radioligand binding assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Subcellular | Cell membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Studies of 1<i>H</i>-Imidazo[4,5-<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.64 | 6.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170790 | — | — | 1 | 6.91 |
| CHEMBL5195535 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170790 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL5195535 | — | Ki | = | 427.0 | nM | 6.37 |