Assay Detail
ADMET
CHEMBL5100459
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP1A2 in rat liver Microsome using phenacetin as substrate in presence of NADPH by LC-MS/MS analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Studies of 1<i>H</i>-Imidazo[4,5-<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.46 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5170790 | — | — | 1 | 5.88 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 5.34 |
| CHEMBL5190388 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5170790 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL5190388 | — | IC50 | = | 6990.0 | nM | 5.16 |