Assay Detail
Binding
CHEMBL5104356
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2 (unknown origin) using ULight-4E-BP1 peptide as substrate incubated for 1 hr in presence of ATP by fluorescence based analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.02 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 10.22 |
| CHEMBL5186748 | — | — | 1 | 9.92 |
| CHEMBL5208686 | — | — | 1 | 8.89 |
| CHEMBL5177149 | — | — | 1 | 8.85 |
| CHEMBL5202124 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1336 | SORAFENIB | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL5186748 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL5208686 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5177149 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5202124 | — | IC50 | = | 60.7 | nM | 7.22 |