Assay Detail
Functional
CHEMBL5104522
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.27 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4585178 | — | — | 1 | 6.96 |
| CHEMBL5192457 | — | — | 1 | 6.82 |
| CHEMBL5185867 | — | — | 1 | 6.77 |
| CHEMBL5189034 | — | — | 1 | 6.68 |
| CHEMBL453114 | — | — | 1 | 6.37 |
| CHEMBL4560404 | — | — | 1 | 6.32 |
| CHEMBL509219 | — | — | 1 | 5.92 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | — | 1 | 5.87 |
| CHEMBL454935 | — | — | 1 | 5.55 |
| CHEMBL511104 | — | — | 1 | 5.47 |
| CHEMBL454129 | — | — | 1 | - |
| CHEMBL3317583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4585178 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5192457 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5185867 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5189034 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL453114 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4560404 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL509219 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL394882 | NOR-BETA-LAPACHONE | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL454935 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL511104 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL454129 | — | IC50 | < | 1210.0 | nM | - |
| CHEMBL3317583 | — | IC50 | < | 1250.0 | nM | - |