Assay Detail

CHEMBL5105258

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to N-terminal FLAG tagged beta catenin alpha helix (H1 - 141 to 149 aa) of armadillo repeat domain (unknown origin) by STD/HSQC based NMR analysis

ChEMBL ↗

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Target

Catenin beta-1 (CHEMBL5866) ↗

Open DB target context

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Catenin beta-1 (CHEMBL5866) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Catenin beta-1

CHEMBL5866

Anchored from Assay target.

Protein identity Catenin beta-1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Catenin beta-1 (CHEMBL5866) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Biophysical Survey of Small-Molecule β-Catenin Inhibitors: A Cautionary Tale.

McCoy MA, Spicer D, Wells N, Hoogewijs K, Fiedler M, Baud MGJ.
J Med Chem (2022) 65 : 7246 -7261
PubMed 35581674 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	4.70	4.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL484853	CARNOSIC ACID	—	1	4.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL484853	CARNOSIC ACID	Kd	=	20000.0	nM	4.70