Assay Detail
Functional
CHEMBL5106227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human TMD8 cells incubated for 72 hrs by CellTiter-Glo assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TMD8 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.88 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189426 | — | — | 1 | 9.10 |
| CHEMBL5179080 | — | — | 1 | 8.92 |
| CHEMBL5176551 | — | — | 1 | 8.82 |
| CHEMBL5196932 | — | — | 1 | 8.77 |
| CHEMBL5170833 | — | — | 1 | 8.77 |
| CHEMBL5189231 | — | — | 1 | 8.74 |
| CHEMBL5193942 | — | — | 1 | 8.59 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 8.57 |
| CHEMBL5178389 | — | — | 1 | 8.47 |
| CHEMBL5198455 | — | — | 1 | 8.27 |
| CHEMBL5202754 | — | — | 1 | 8.14 |
| CHEMBL5180302 | — | — | 1 | 8.04 |
| CHEMBL5177044 | — | — | 1 | 7.92 |
| CHEMBL5195504 | — | — | 1 | 7.89 |
| CHEMBL5192748 | — | — | 1 | 7.81 |
| CHEMBL5204458 | — | — | 1 | 7.65 |
| CHEMBL5205889 | — | — | 1 | 7.65 |
| CHEMBL5208265 | — | — | 1 | 7.61 |
| CHEMBL5193597 | — | — | 1 | 7.55 |
| CHEMBL5175574 | — | — | 1 | 7.51 |
| CHEMBL5170025 | — | — | 1 | 7.42 |
| CHEMBL4072833 | EVOBRUTINIB | 3.0 | 1 | 7.25 |
| CHEMBL5206496 | — | — | 1 | 7.08 |
| CHEMBL5206093 | — | — | 1 | 6.50 |
| CHEMBL5206716 | — | — | 1 | 6.34 |
| CHEMBL5171858 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189426 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL5179080 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5176551 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5196932 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5170833 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5189231 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL5193942 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL5178389 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL5198455 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL5202754 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5180302 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL5177044 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL5195504 | — | IC50 | = | 12.9 | nM | 7.89 |
| CHEMBL5192748 | — | IC50 | = | 15.6 | nM | 7.81 |
| CHEMBL5204458 | — | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL5205889 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL5208265 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL5193597 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL5175574 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL5170025 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL4072833 | EVOBRUTINIB | IC50 | = | 56.2 | nM | 7.25 |
| CHEMBL5206496 | — | IC50 | = | 84.1 | nM | 7.08 |
| CHEMBL5206093 | — | IC50 | = | 319.8 | nM | 6.50 |
| CHEMBL5206716 | — | IC50 | = | 454.5 | nM | 6.34 |
| CHEMBL5171858 | — | IC50 | = | 2526.0 | nM | 5.60 |