Assay Detail
Binding
CHEMBL5106947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at P2X4R (unknown origin) expressed in 1321N1 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 1321N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2<i>H</i>-naphtho[1,2-<i>b</i>][1,4]diazepine-2,4(3<i>H</i>)-diones as P2X4 Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.50 | 5.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1532400 | — | — | 1 | 5.71 |
| CHEMBL2180179 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1532400 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL2180179 | — | IC50 | = | 5200.0 | nM | 5.28 |