Assay Detail
Binding
CHEMBL5107170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protac activity at His-tagged CRBN/FLAG-tagged DDB1 (unknown origin) in presence of Cy5-labeled thalidomide incubated for 60 min by TR-FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/DNA damage-binding protein 1 (CHEMBL4630734) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Linker-Dependent Folding Rationalizes PROTAC Cell Permeability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.21 | 9.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5178566 | — | — | 1 | 9.61 |
| CHEMBL4848064 | — | — | 1 | 9.18 |
| CHEMBL4854720 | — | — | 1 | 8.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5178566 | — | IC50 | = | 0.244 | nM | 9.61 |
| CHEMBL4848064 | — | IC50 | = | 0.667 | nM | 9.18 |
| CHEMBL4854720 | — | IC50 | = | 1.41 | nM | 8.85 |