Assay Detail
Binding
CHEMBL5107331
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Agonist activity at human STING HAQ expressed in 293T cells by digitonin cell based assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 28 | 6.55 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4465054 | — | — | 1 | 7.68 |
| CHEMBL5208313 | — | — | 1 | 7.22 |
| CHEMBL5181208 | — | — | 1 | 7.09 |
| CHEMBL5172826 | — | — | 1 | 6.95 |
| CHEMBL4449584 | — | — | 1 | 6.91 |
| CHEMBL5194586 | — | — | 1 | 6.90 |
| CHEMBL5204387 | — | — | 1 | 6.88 |
| CHEMBL5189981 | — | — | 1 | 6.88 |
| CHEMBL5179761 | — | — | 1 | 6.79 |
| CHEMBL5187347 | — | — | 1 | 6.76 |
| CHEMBL5208206 | — | — | 1 | 6.76 |
| CHEMBL4435159 | — | — | 1 | 6.72 |
| CHEMBL5175129 | — | — | 1 | 6.71 |
| CHEMBL5180218 | — | — | 1 | 6.61 |
| CHEMBL5093161 | — | — | 1 | 6.58 |
| CHEMBL5180332 | — | — | 1 | 6.43 |
| CHEMBL5204143 | — | — | 1 | 6.42 |
| CHEMBL5185176 | — | — | 1 | 6.39 |
| CHEMBL5176230 | — | — | 1 | 6.30 |
| CHEMBL5184506 | — | — | 1 | 6.30 |
| CHEMBL5191052 | — | — | 1 | 6.16 |
| CHEMBL5194710 | — | — | 1 | 6.05 |
| CHEMBL5200248 | — | — | 1 | 6.05 |
| CHEMBL5185627 | — | — | 1 | 5.86 |
| CHEMBL5198498 | — | — | 1 | 5.79 |
| CHEMBL5176694 | — | — | 1 | 5.03 |
| CHEMBL5188919 | — | — | 1 | - |
| CHEMBL5187328 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4465054 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5208313 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5181208 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5172826 | — | EC50 | = | 113.0 | nM | 6.95 |
| CHEMBL4449584 | — | EC50 | = | 123.0 | nM | 6.91 |
| CHEMBL5194586 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5204387 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5189981 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL5179761 | — | EC50 | = | 163.0 | nM | 6.79 |
| CHEMBL5187347 | — | EC50 | = | 173.0 | nM | 6.76 |
| CHEMBL5208206 | — | EC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4435159 | — | EC50 | = | 189.0 | nM | 6.72 |
| CHEMBL5175129 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL5180218 | — | EC50 | = | 243.0 | nM | 6.61 |
| CHEMBL5093161 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5180332 | — | EC50 | = | 367.0 | nM | 6.43 |
| CHEMBL5204143 | — | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL5185176 | — | EC50 | = | 403.0 | nM | 6.39 |
| CHEMBL5176230 | — | EC50 | = | 503.0 | nM | 6.30 |
| CHEMBL5184506 | — | EC50 | = | 497.0 | nM | 6.30 |
| CHEMBL5191052 | — | EC50 | = | 695.0 | nM | 6.16 |
| CHEMBL5194710 | — | EC50 | = | 896.0 | nM | 6.05 |
| CHEMBL5200248 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5185627 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL5198498 | — | EC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5176694 | — | EC50 | = | 9420.0 | nM | 5.03 |
| CHEMBL5188919 | — | EC50 | > | 45000.0 | nM | - |
| CHEMBL5187328 | — | EC50 | > | 45000.0 | nM | - |