Assay Detail
Functional
CHEMBL5107337
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Induction of TNFalpha secretion in human PBMC incubated for 16 hrs
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 4.59 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5175129 | — | — | 1 | 5.84 |
| CHEMBL5208206 | — | — | 1 | 5.58 |
| CHEMBL5179761 | — | — | 1 | 5.17 |
| CHEMBL5187347 | — | — | 1 | 4.87 |
| CHEMBL4449584 | — | — | 1 | 4.73 |
| CHEMBL5208313 | — | — | 1 | 4.61 |
| CHEMBL4465054 | — | — | 1 | 4.44 |
| CHEMBL5185176 | — | — | 1 | 4.42 |
| CHEMBL5172826 | — | — | 1 | 4.36 |
| CHEMBL4435159 | — | — | 1 | 4.35 |
| CHEMBL5181208 | — | — | 1 | 4.30 |
| CHEMBL5204143 | — | — | 1 | 4.28 |
| CHEMBL5189981 | — | — | 1 | 4.27 |
| CHEMBL5180332 | — | — | 1 | 4.18 |
| CHEMBL5176230 | — | — | 1 | 4.00 |
| CHEMBL5191052 | — | — | 1 | 4.00 |
| CHEMBL5200248 | — | — | 1 | - |
| CHEMBL5198498 | — | — | 1 | - |
| CHEMBL5184506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5175129 | — | EC50 | = | 1430.0 | nM | 5.84 |
| CHEMBL5208206 | — | EC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL5179761 | — | EC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL5187347 | — | EC50 | = | 13640.0 | nM | 4.87 |
| CHEMBL4449584 | — | EC50 | = | 18720.0 | nM | 4.73 |
| CHEMBL5208313 | — | EC50 | = | 24560.0 | nM | 4.61 |
| CHEMBL4465054 | — | EC50 | = | 36030.0 | nM | 4.44 |
| CHEMBL5185176 | — | EC50 | = | 37590.0 | nM | 4.42 |
| CHEMBL5172826 | — | EC50 | = | 43380.0 | nM | 4.36 |
| CHEMBL4435159 | — | EC50 | = | 44540.0 | nM | 4.35 |
| CHEMBL5181208 | — | EC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL5204143 | — | EC50 | = | 52450.0 | nM | 4.28 |
| CHEMBL5189981 | — | EC50 | = | 53860.0 | nM | 4.27 |
| CHEMBL5180332 | — | EC50 | = | 65770.0 | nM | 4.18 |
| CHEMBL5176230 | — | EC50 | = | 99700.0 | nM | 4.00 |
| CHEMBL5191052 | — | EC50 | = | 98800.0 | nM | 4.00 |
| CHEMBL5200248 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL5198498 | — | EC50 | > | 200000.0 | nM | - |
| CHEMBL5184506 | — | EC50 | > | 200000.0 | nM | - |