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Assay Detail

CHEMBL5107359

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human D-423MG cells assessed as cell growth inhibition incubated for 6 days by cystal violet staining based analysis
34
Total Activities
34
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type D-423MG
Confidence 1 — Organism
Curated By Autocuration

Target

D-423MG (CHEMBL2366134)
Type CELL-LINE
Organism Homo sapiens

Publication

Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of <i>ENO1</i>-Deleted Cancers.
Yan VC, Pham CD, Ballato ES, Yang KL, Arthur K, Khadka S, Barekatain Y, Shrestha P, Tran T, Poral AH, Washington M, Raghavan S, Czako B, Pisaneschi F, Lin YH, Satani N, Hammoudi N, Ackroyd JJ, Georgiou DK, Millward SW, Muller FL.
J Med Chem (2022) 65 : 13813 -13832
PubMed 36251833 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 32 6.77 7.80
Activity 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5201200 1 7.80
CHEMBL5191849 1 7.80
CHEMBL5207017 1 7.72
CHEMBL5204791 1 7.72
CHEMBL4759575 1 7.64
CHEMBL4647008 1 7.54
CHEMBL5184125 1 7.41
CHEMBL5187846 1 7.34
CHEMBL4791988 1 7.21
CHEMBL5184702 1 7.20
CHEMBL5208721 1 7.15
CHEMBL4753028 1 7.09
CHEMBL4756379 1 7.01
CHEMBL4798929 1 6.97
CHEMBL4782028 1 6.94
CHEMBL4760369 1 6.92
CHEMBL5179932 1 6.91
CHEMBL4741311 1 6.87
CHEMBL4800502 1 6.70
CHEMBL5174536 1 6.68
CHEMBL4742665 1 6.64
CHEMBL4744031 1 6.59
CHEMBL4643988 1 6.52
CHEMBL5203049 1 6.20
CHEMBL4647387 1 5.89
CHEMBL4763252 1 5.87
CHEMBL4760506 1 5.55
CHEMBL5189876 1 5.54
CHEMBL5194577 1 5.17
CHEMBL5203340 1 4.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5201200 IC50 = 16.0 nM 7.80
CHEMBL5191849 IC50 = 16.0 nM 7.80
CHEMBL5207017 IC50 = 19.0 nM 7.72
CHEMBL5204791 IC50 = 19.0 nM 7.72
CHEMBL4759575 IC50 = 23.0 nM 7.64
CHEMBL4647008 IC50 = 29.0 nM 7.54
CHEMBL5184125 IC50 = 39.0 nM 7.41
CHEMBL5187846 IC50 = 46.0 nM 7.34
CHEMBL4791988 IC50 = 62.0 nM 7.21
CHEMBL5184702 IC50 = 63.0 nM 7.20
CHEMBL5208721 IC50 = 71.0 nM 7.15
CHEMBL4753028 IC50 = 81.0 nM 7.09
CHEMBL4756379 IC50 = 97.0 nM 7.01
CHEMBL4798929 IC50 = 108.0 nM 6.97
CHEMBL4782028 IC50 = 116.0 nM 6.94
CHEMBL4760369 IC50 = 120.0 nM 6.92
CHEMBL5179932 IC50 = 124.0 nM 6.91
CHEMBL4741311 IC50 = 136.0 nM 6.87
CHEMBL4800502 IC50 = 202.0 nM 6.70
CHEMBL5174536 IC50 = 207.0 nM 6.68
CHEMBL4742665 IC50 = 227.0 nM 6.64
CHEMBL4744031 IC50 = 258.0 nM 6.59
CHEMBL4643988 IC50 = 299.0 nM 6.52
CHEMBL5203049 IC50 = 625.0 nM 6.20
CHEMBL4647387 IC50 = 1300.0 nM 5.89
CHEMBL4763252 IC50 = 1342.0 nM 5.87
CHEMBL4760506 IC50 = 2807.0 nM 5.55
CHEMBL5189876 IC50 = 2874.0 nM 5.54
CHEMBL5194577 IC50 = 6676.0 nM 5.17
CHEMBL5203340 IC50 = 36560.0 nM 4.44
CHEMBL4633981 Activity - -
CHEMBL5174646 IC50 > 100000.0 nM -
CHEMBL5199120 IC50 > 100000.0 nM -
CHEMBL5195662 Activity - -