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Assay Detail

CHEMBL5107409

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antibacterial activity against efflux pump lacking/recombinant OM pore producing Pseudomonas aeruginosa assessed as inhibition of bacterial growth
80
Total Activities
80
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Pseudomonas aeruginosa
Confidence 1 — Organism
Curated By Autocuration

Target

Pseudomonas aeruginosa (CHEMBL348)
Type ORGANISM
Organism Pseudomonas aeruginosa

Publication

Structure-Uptake Relationship Studies of Oxazolidinones in Gram-Negative ESKAPE Pathogens.
Hu Z, Leus IV, Chandar B, Sherborne BS, Avila QP, Rybenkov VV, Zgurskaya HI, Duerfeldt AS.
J Med Chem (2022) 65 : 14144 -14179
PubMed 36257060 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 80 5.24 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5179367 1 7.70
CHEMBL5200254 1 7.00
CHEMBL5179818 1 6.70
CHEMBL5201079 1 6.52
CHEMBL5193259 1 6.00
CHEMBL5206342 1 5.96
CHEMBL5176762 1 5.92
CHEMBL5209470 1 5.92
CHEMBL5190226 1 5.85
CHEMBL5202385 1 5.85
CHEMBL126 LINEZOLID 4.0 1 5.77
CHEMBL5197646 1 5.75
CHEMBL5205866 1 5.66
CHEMBL5202730 1 5.54
CHEMBL5190363 1 5.51
CHEMBL5186560 1 5.42
CHEMBL5181450 1 5.26
CHEMBL5208917 1 5.24
CHEMBL5178366 1 5.22
CHEMBL5204810 1 5.16
CHEMBL5179408 1 5.09
CHEMBL5195466 1 5.05
CHEMBL5180592 1 5.03
CHEMBL5189056 1 4.89
CHEMBL5175197 1 4.79
CHEMBL5196659 1 4.74
CHEMBL5193767 1 4.65
CHEMBL5173353 1 4.59
CHEMBL5185676 1 4.52
CHEMBL5191488 1 4.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5179367 IC50 = 20.0 nM 7.70
CHEMBL5200254 IC50 = 100.0 nM 7.00
CHEMBL5179818 IC50 = 200.0 nM 6.70
CHEMBL5201079 IC50 = 300.0 nM 6.52
CHEMBL5193259 IC50 = 1000.0 nM 6.00
CHEMBL5206342 IC50 = 1100.0 nM 5.96
CHEMBL5176762 IC50 = 1200.0 nM 5.92
CHEMBL5209470 IC50 = 1200.0 nM 5.92
CHEMBL5190226 IC50 = 1400.0 nM 5.85
CHEMBL5202385 IC50 = 1400.0 nM 5.85
CHEMBL126 LINEZOLID IC50 = 1700.0 nM 5.77
CHEMBL5197646 IC50 = 1800.0 nM 5.75
CHEMBL5205866 IC50 = 2200.0 nM 5.66
CHEMBL5202730 IC50 = 2900.0 nM 5.54
CHEMBL5190363 IC50 = 3100.0 nM 5.51
CHEMBL5186560 IC50 = 3800.0 nM 5.42
CHEMBL5181450 IC50 = 5500.0 nM 5.26
CHEMBL5208917 IC50 = 5800.0 nM 5.24
CHEMBL5178366 IC50 = 6000.0 nM 5.22
CHEMBL5204810 IC50 = 6900.0 nM 5.16
CHEMBL5179408 IC50 = 8100.0 nM 5.09
CHEMBL5195466 IC50 = 8900.0 nM 5.05
CHEMBL5180592 IC50 = 9400.0 nM 5.03
CHEMBL5189056 IC50 = 13000.0 nM 4.89
CHEMBL5175197 IC50 = 16200.0 nM 4.79
CHEMBL5196659 IC50 = 18100.0 nM 4.74
CHEMBL5193767 IC50 = 22300.0 nM 4.65
CHEMBL5173353 IC50 = 25700.0 nM 4.59
CHEMBL5185676 IC50 = 29900.0 nM 4.52
CHEMBL5191488 IC50 = 30100.0 nM 4.52
CHEMBL5209375 IC50 = 32900.0 nM 4.48
CHEMBL5173883 IC50 = 33000.0 nM 4.48
CHEMBL5193973 IC50 = 36600.0 nM 4.44
CHEMBL5201237 IC50 = 37900.0 nM 4.42
CHEMBL5180857 IC50 = 38700.0 nM 4.41
CHEMBL5181242 IC50 = 40400.0 nM 4.39
CHEMBL5180265 IC50 = 42300.0 nM 4.37
CHEMBL5172433 IC50 = 46900.0 nM 4.33
CHEMBL5193171 IC50 = 47400.0 nM 4.32
CHEMBL5185157 IC50 = 91300.0 nM 4.04
CHEMBL5183837 IC50 > 100000.0 nM -
CHEMBL5183983 IC50 > 100000.0 nM -
CHEMBL5195057 IC50 > 100000.0 nM -
CHEMBL5192651 IC50 > 100000.0 nM -
CHEMBL5183209 IC50 > 100000.0 nM -
CHEMBL5175286 IC50 > 100000.0 nM -
CHEMBL5174558 IC50 > 100000.0 nM -
CHEMBL5196762 IC50 > 100000.0 nM -
CHEMBL5173020 IC50 > 100000.0 nM -
CHEMBL5200667 IC50 > 100000.0 nM -