Assay Detail
Functional
CHEMBL5108754
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Nipah B2004 infected in human NCI-H358 cells assessed as reduction in viral replication incubated for 48 to 144 hrs by reporter virus assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Henipavirus nipahense |
| Cell Type | NCI-H358 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.56 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205032 | — | — | 1 | 7.50 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205032 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 2460.0 | nM | 5.61 |