Assay Detail
Functional
CHEMBL5108772
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Antiviral activity against SARS-CoV-2 infected in human Calu-3 cells assessed as reduction in viral replication at MOI of 0.01 measured after 72 hrs by qRT-PCR analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Calu-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Phosphoramidate Prodrugs Continue to Deliver, The Journey of Remdesivir (GS-5734) from RSV to SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.78 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5205032 | — | — | 1 | 6.96 |
| CHEMBL2016757 | GS-441524 | 1.0 | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5205032 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2016757 | GS-441524 | EC50 | = | 250.0 | nM | 6.60 |