Assay Detail
Binding
CHEMBL5108965
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Inhibition of BCR-ABL (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The progress of small-molecules and degraders against BCR-ABL for the treatment of CML.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.53 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 9.00 |
| CHEMBL4297524 | RADOTINIB | 3.0 | 1 | 8.92 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.85 |
| CHEMBL384575 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255863 | NILOTINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4297524 | RADOTINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL384575 | — | IC50 | = | 47.0 | nM | 7.33 |