Assay Detail
Binding
CHEMBL5108988
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BCR-ABL Y253H mutant phosphorylation in mouse BaF3 cells incubated for 4 hrs by immunoblotting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The progress of small-molecules and degraders against BCR-ABL for the treatment of CML.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.81 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4130229 | VODOBATINIB | 2.0 | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4130229 | VODOBATINIB | IC50 | = | 154.0 | nM | 6.81 |