Assay Detail
Binding
CHEMBL5109059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EZH2 A677G mutant (unknown origin) by AlphaLISA assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase EZH2 (CHEMBL2189110) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting EZH2 for cancer therapy: From current progress to novel strategies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.32 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5196492 | — | — | 1 | 8.40 |
| CHEMBL4637350 | — | — | 1 | 8.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5196492 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4637350 | — | IC50 | = | 5.9 | nM | 8.23 |