Assay Detail
Binding
CHEMBL5109291
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Inhibition of DENV2 NS2B-NS3 protease using Bz-Nle-Lys-Arg-Arg-AMC as substrate by spectrofluorometer analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Seeking heterocyclic scaffolds as antivirals against dengue virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.07 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1729965 | — | — | 1 | 5.70 |
| CHEMBL5191539 | — | — | 1 | 5.59 |
| CHEMBL5174495 | — | — | 1 | 5.28 |
| CHEMBL5185808 | — | — | 1 | 5.18 |
| CHEMBL3938548 | — | — | 1 | 5.08 |
| CHEMBL3219169 | — | — | 1 | 4.38 |
| CHEMBL320007 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1729965 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL5191539 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL5174495 | — | IC50 | = | 5280.0 | nM | 5.28 |
| CHEMBL5185808 | — | IC50 | = | 6660.0 | nM | 5.18 |
| CHEMBL3938548 | — | IC50 | = | 8240.0 | nM | 5.08 |
| CHEMBL3219169 | — | IC50 | = | 41800.0 | nM | 4.38 |
| CHEMBL320007 | — | IC50 | = | 52700.0 | nM | 4.28 |