Assay Detail

CHEMBL5109339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of recombinant Cdc2/CycB (unknown origin)

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Current progress and novel strategies that target CDK12 for drug discovery.

Lei P, Zhang J, Liao P, Ren C, Wang J, Wang Y.
Eur J Med Chem (2022) 240 : 114603 -114603
PubMed 35868123 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.31	8.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL23327	PURVALANOLA	—	1	8.40
CHEMBL23254	PURVALANOL B	—	1	8.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL23327	PURVALANOLA	IC50	=	4.0	nM	8.40
CHEMBL23254	PURVALANOL B	IC50	=	6.0	nM	8.22