Assay Detail
Binding
CHEMBL5109361
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Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pre-incubated for 5 mins followed by substrate addition and measured after 6 mins by Ellman's method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.54 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.82 |
| CHEMBL5205870 | — | — | 1 | 4.25 |
| CHEMBL5178427 | — | — | 1 | - |
| CHEMBL5169582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5205870 | — | IC50 | = | 56200.0 | nM | 4.25 |
| CHEMBL5178427 | — | IC50 | = | 595700.0 | nM | - |
| CHEMBL5169582 | — | IC50 | = | 607000.0 | nM | - |