Assay Detail
Binding
CHEMBL5109369
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Inhibition of TRKC (unknown origin) in presence of [gamma33P]ATP by radiometric HotSpot assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.18 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3889654 | LAROTRECTINIB | 4.0 | 1 | 8.68 |
| CHEMBL5198364 | — | — | 1 | 7.88 |
| CHEMBL4456471 | — | — | 1 | 7.48 |
| CHEMBL4473123 | — | — | 1 | 7.38 |
| CHEMBL4470728 | — | — | 1 | 7.37 |
| CHEMBL4571608 | — | — | 1 | 6.80 |
| CHEMBL4437322 | — | — | 1 | 6.49 |
| CHEMBL4440687 | — | — | 1 | 6.36 |
| CHEMBL3891994 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3889654 | LAROTRECTINIB | IC50 | = | 2.08 | nM | 8.68 |
| CHEMBL5198364 | — | IC50 | = | 13.02 | nM | 7.88 |
| CHEMBL4456471 | — | IC50 | = | 33.37 | nM | 7.48 |
| CHEMBL4473123 | — | IC50 | = | 41.62 | nM | 7.38 |
| CHEMBL4470728 | — | IC50 | = | 43.07 | nM | 7.37 |
| CHEMBL4571608 | — | IC50 | = | 156.7 | nM | 6.80 |
| CHEMBL4437322 | — | IC50 | = | 323.6 | nM | 6.49 |
| CHEMBL4440687 | — | IC50 | = | 442.0 | nM | 6.36 |
| CHEMBL3891994 | — | IC50 | = | 700.0 | nM | 6.16 |