Assay Detail
Functional
CHEMBL5109394
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Antiproliferative activity against human MIA PaCa-2 cells harboring KRAS,TP53,CDKN2A and DPC4/SMAD4 mutations assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.92 | 7.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5188293 | — | — | 1 | 7.90 |
| CHEMBL5176990 | — | — | 1 | 6.63 |
| CHEMBL5170906 | — | — | 1 | 6.34 |
| CHEMBL5190968 | — | — | 1 | 6.34 |
| CHEMBL5177168 | — | — | 1 | 6.21 |
| CHEMBL5204729 | — | — | 1 | 6.15 |
| CHEMBL5196177 | — | — | 1 | 6.12 |
| CHEMBL5186801 | — | — | 1 | 5.95 |
| CHEMBL5206909 | — | — | 1 | 5.93 |
| CHEMBL5199835 | — | — | 1 | 5.91 |
| CHEMBL5198068 | — | — | 1 | 5.91 |
| CHEMBL5176233 | — | — | 1 | 5.91 |
| CHEMBL5177776 | — | — | 1 | 5.72 |
| CHEMBL5180558 | — | — | 1 | 5.67 |
| CHEMBL5178369 | — | — | 1 | 5.33 |
| CHEMBL5195974 | — | — | 1 | 5.32 |
| CHEMBL5187385 | — | — | 1 | 5.30 |
| CHEMBL458997 | — | — | 1 | 5.28 |
| CHEMBL5197230 | — | — | 1 | 5.28 |
| CHEMBL5192604 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5188293 | — | IC50 | = | 12.63 | nM | 7.90 |
| CHEMBL5176990 | — | IC50 | = | 235.4 | nM | 6.63 |
| CHEMBL5170906 | — | IC50 | = | 451.8 | nM | 6.34 |
| CHEMBL5190968 | — | IC50 | = | 459.2 | nM | 6.34 |
| CHEMBL5177168 | — | IC50 | = | 621.9 | nM | 6.21 |
| CHEMBL5204729 | — | IC50 | = | 713.9 | nM | 6.15 |
| CHEMBL5196177 | — | IC50 | = | 767.9 | nM | 6.12 |
| CHEMBL5186801 | — | IC50 | = | 1133.0 | nM | 5.95 |
| CHEMBL5206909 | — | IC50 | = | 1166.0 | nM | 5.93 |
| CHEMBL5199835 | — | IC50 | = | 1233.0 | nM | 5.91 |
| CHEMBL5198068 | — | IC50 | = | 1233.0 | nM | 5.91 |
| CHEMBL5176233 | — | IC50 | = | 1229.0 | nM | 5.91 |
| CHEMBL5177776 | — | IC50 | = | 1905.0 | nM | 5.72 |
| CHEMBL5180558 | — | IC50 | = | 2125.0 | nM | 5.67 |
| CHEMBL5178369 | — | IC50 | = | 4708.0 | nM | 5.33 |
| CHEMBL5195974 | — | IC50 | = | 4755.0 | nM | 5.32 |
| CHEMBL5187385 | — | IC50 | = | 5047.0 | nM | 5.30 |
| CHEMBL458997 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL5197230 | — | IC50 | = | 5274.0 | nM | 5.28 |
| CHEMBL5192604 | — | IC50 | = | 7088.0 | nM | 5.15 |