Assay Detail
Functional
CHEMBL5109396
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Antiproliferative activity against bortezomib- resistant human KM3/BTZ cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KM3/BTZ |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and activity evaluation of isopropylsulfonyl-substituted 2,4- diarylaminopyrimidine derivatives as FAK inhibitors for the potential treatment of pancreatic cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.78 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176990 | — | — | 1 | 6.80 |
| CHEMBL5192604 | — | — | 1 | 6.58 |
| CHEMBL5190968 | — | — | 1 | 6.30 |
| CHEMBL5186801 | — | — | 1 | 5.99 |
| CHEMBL5204729 | — | — | 1 | 5.79 |
| CHEMBL5187385 | — | — | 1 | 5.67 |
| CHEMBL5196177 | — | — | 1 | 5.64 |
| CHEMBL5197230 | — | — | 1 | 5.63 |
| CHEMBL5170906 | — | — | 1 | 5.60 |
| CHEMBL5177776 | — | — | 1 | 5.59 |
| CHEMBL5176233 | — | — | 1 | 5.54 |
| CHEMBL5180558 | — | — | 1 | 5.43 |
| CHEMBL458997 | — | — | 1 | 5.36 |
| CHEMBL5177168 | — | — | 1 | 5.01 |
| CHEMBL5178369 | — | — | 1 | - |
| CHEMBL5195974 | — | — | 1 | - |
| CHEMBL5188293 | — | — | 1 | - |
| CHEMBL5199835 | — | — | 1 | - |
| CHEMBL5206909 | — | — | 1 | - |
| CHEMBL5198068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176990 | — | IC50 | = | 158.6 | nM | 6.80 |
| CHEMBL5192604 | — | IC50 | = | 262.3 | nM | 6.58 |
| CHEMBL5190968 | — | IC50 | = | 496.6 | nM | 6.30 |
| CHEMBL5186801 | — | IC50 | = | 1025.0 | nM | 5.99 |
| CHEMBL5204729 | — | IC50 | = | 1613.0 | nM | 5.79 |
| CHEMBL5187385 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5196177 | — | IC50 | = | 2286.0 | nM | 5.64 |
| CHEMBL5197230 | — | IC50 | = | 2315.0 | nM | 5.63 |
| CHEMBL5170906 | — | IC50 | = | 2491.0 | nM | 5.60 |
| CHEMBL5177776 | — | IC50 | = | 2581.0 | nM | 5.59 |
| CHEMBL5176233 | — | IC50 | = | 2886.0 | nM | 5.54 |
| CHEMBL5180558 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL458997 | — | IC50 | = | 4386.0 | nM | 5.36 |
| CHEMBL5177168 | — | IC50 | = | 9772.0 | nM | 5.01 |
| CHEMBL5178369 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5195974 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5188293 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5199835 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5206909 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5198068 | — | IC50 | > | 10000.0 | nM | - |