Assay Detail
Toxicity
CHEMBL5109448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hERG
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.15 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5195940 | — | — | 1 | 5.70 |
| CHEMBL5176315 | — | — | 1 | 5.30 |
| CHEMBL5175037 | — | — | 1 | 4.92 |
| CHEMBL5198622 | — | — | 1 | 4.66 |
| CHEMBL5201614 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5195940 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL5176315 | — | IC50 | = | 5060.0 | nM | 5.30 |
| CHEMBL5175037 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5198622 | — | IC50 | = | 21970.0 | nM | 4.66 |
| CHEMBL5201614 | — | IC50 | > | 30000.0 | nM | - |