Assay Detail
Functional
CHEMBL5109650
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human 2008 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 2008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.91 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5198898 | — | — | 1 | 9.80 |
| CHEMBL5206615 | — | — | 1 | 8.39 |
| CHEMBL5191443 | — | — | 1 | 8.12 |
| CHEMBL5202359 | — | — | 1 | 7.99 |
| CHEMBL5171746 | — | — | 1 | 7.93 |
| CHEMBL5202993 | — | — | 1 | 7.65 |
| CHEMBL307794 | — | — | 1 | 7.43 |
| CHEMBL5176513 | — | — | 1 | 7.41 |
| CHEMBL5197149 | — | — | 1 | 7.30 |
| CHEMBL5075549 | — | — | 1 | 7.03 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5198898 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5206615 | — | IC50 | = | 4.03 | nM | 8.39 |
| CHEMBL5191443 | — | IC50 | = | 7.67 | nM | 8.12 |
| CHEMBL5202359 | — | IC50 | = | 10.25 | nM | 7.99 |
| CHEMBL5171746 | — | IC50 | = | 11.64 | nM | 7.93 |
| CHEMBL5202993 | — | IC50 | = | 22.36 | nM | 7.65 |
| CHEMBL307794 | — | IC50 | = | 37.28 | nM | 7.43 |
| CHEMBL5176513 | — | IC50 | = | 39.2 | nM | 7.41 |
| CHEMBL5197149 | — | IC50 | = | 49.73 | nM | 7.30 |
| CHEMBL5075549 | — | IC50 | = | 93.47 | nM | 7.03 |
| CHEMBL84 | TOPOTECAN | IC50 | > | 500.0 | nM | - |