Assay Detail
Functional
CHEMBL5109651
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human SW-620 cells assessed as inhibition of cell growth incubated for 72 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 9.08 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5202359 | — | — | 1 | 9.96 |
| CHEMBL5171746 | — | — | 1 | 9.77 |
| CHEMBL5191443 | — | — | 1 | 9.55 |
| CHEMBL5206615 | — | — | 1 | 9.54 |
| CHEMBL5176513 | — | — | 1 | 9.44 |
| CHEMBL5202993 | — | — | 1 | 9.08 |
| CHEMBL307794 | — | — | 1 | 9.03 |
| CHEMBL5197149 | — | — | 1 | 8.84 |
| CHEMBL5075549 | — | — | 1 | 8.57 |
| CHEMBL5198898 | — | — | 1 | 6.99 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5202359 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5171746 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL5191443 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL5206615 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL5176513 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL5202993 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL307794 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL5197149 | — | IC50 | = | 1.44 | nM | 8.84 |
| CHEMBL5075549 | — | IC50 | = | 2.67 | nM | 8.57 |
| CHEMBL5198898 | — | IC50 | = | 101.6 | nM | 6.99 |
| CHEMBL84 | TOPOTECAN | IC50 | > | 500.0 | nM | - |