Assay Detail

CHEMBL5109991

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Functional

Inverse agonist activity at 5-HT2C receptor (unknown origin)

ChEMBL ↗

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Target

5-hydroxytryptamine receptor 2C (CHEMBL225) ↗

Open DB target context

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5-hydroxytryptamine receptor 2C (CHEMBL225) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 5-hydroxytryptamine receptor 2C

CHEMBL225

Anchored from Assay target.

Protein identity 5-hydroxytryptamine receptor 2C

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

5-hydroxytryptamine receptor 2C (CHEMBL225) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.

Fu H, Rong J, Chen Z, Zhou J, Collier T, Liang SH.
J Med Chem (2022) 65 : 10755 -10808
PubMed 35939391 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.82	8.82

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2111101	PIMAVANSERIN	4.0	1	8.82

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2111101	PIMAVANSERIN	Ki	=	1.5	nM	8.82