Assay Detail
Binding
CHEMBL5110022
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Binding affinity to human recombinant 5-HT7 receptor expressed in CHO cells assessed as inhibition constant
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.88 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5179460 | — | — | 1 | 9.77 |
| CHEMBL5196234 | — | — | 1 | 9.66 |
| CHEMBL5184712 | — | — | 1 | 9.49 |
| CHEMBL5196950 | — | — | 1 | 8.72 |
| CHEMBL5172635 | — | — | 1 | 8.59 |
| CHEMBL5173014 | — | — | 1 | 8.12 |
| CHEMBL5180129 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5179460 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL5196234 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL5184712 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL5196950 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL5172635 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL5173014 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL5180129 | — | Ki | = | 16.0 | nM | 7.80 |