Assay Detail
Functional
CHEMBL5111286
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATP production in human MKN-45 cells incubated for 20 to 24 hrs by ATP assay kit method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr<sup>705</sup>/Ser<sup>727</sup> Inhibitory Activity for Gastric Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.87 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176684 | — | — | 1 | 7.61 |
| CHEMBL5196490 | — | — | 1 | 7.25 |
| CHEMBL5182844 | — | — | 1 | 7.14 |
| CHEMBL5176948 | — | — | 1 | 7.06 |
| CHEMBL5170615 | — | — | 1 | 7.03 |
| CHEMBL5171708 | — | — | 1 | 7.01 |
| CHEMBL5177332 | — | — | 1 | 6.70 |
| CHEMBL5199234 | — | — | 1 | 6.66 |
| CHEMBL5189947 | — | — | 1 | 6.62 |
| CHEMBL5185530 | — | — | 1 | 6.28 |
| CHEMBL5182625 | — | — | 1 | 6.22 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176684 | — | IC50 | = | 24.7 | nM | 7.61 |
| CHEMBL5196490 | — | IC50 | = | 55.9 | nM | 7.25 |
| CHEMBL5182844 | — | IC50 | = | 72.5 | nM | 7.14 |
| CHEMBL5176948 | — | IC50 | = | 87.6 | nM | 7.06 |
| CHEMBL5170615 | — | IC50 | = | 93.2 | nM | 7.03 |
| CHEMBL5171708 | — | IC50 | = | 97.8 | nM | 7.01 |
| CHEMBL5177332 | — | IC50 | = | 200.1 | nM | 6.70 |
| CHEMBL5199234 | — | IC50 | = | 217.6 | nM | 6.66 |
| CHEMBL5189947 | — | IC50 | = | 241.8 | nM | 6.62 |
| CHEMBL5185530 | — | IC50 | = | 519.6 | nM | 6.28 |
| CHEMBL5182625 | — | IC50 | = | 598.5 | nM | 6.22 |
| CHEMBL64130 | NAPABUCASIN | IC50 | - | — | - |