Assay Detail
Functional
CHEMBL5111287
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MKN-45 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr<sup>705</sup>/Ser<sup>727</sup> Inhibitory Activity for Gastric Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.28 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5176684 | — | — | 1 | 8.03 |
| CHEMBL5182625 | — | — | 1 | 7.79 |
| CHEMBL5182844 | — | — | 1 | 7.74 |
| CHEMBL5199234 | — | — | 1 | 7.67 |
| CHEMBL5171708 | — | — | 1 | 7.61 |
| CHEMBL5170615 | — | — | 1 | 7.44 |
| CHEMBL5196490 | — | — | 1 | 7.38 |
| CHEMBL5189947 | — | — | 1 | 7.30 |
| CHEMBL5177332 | — | — | 1 | 7.26 |
| CHEMBL5185530 | — | — | 1 | 6.96 |
| CHEMBL5176948 | — | — | 1 | 6.82 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5176684 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5182625 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL5182844 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL5199234 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL5171708 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL5170615 | — | IC50 | = | 36.4 | nM | 7.44 |
| CHEMBL5196490 | — | IC50 | = | 41.6 | nM | 7.38 |
| CHEMBL5189947 | — | IC50 | = | 49.5 | nM | 7.30 |
| CHEMBL5177332 | — | IC50 | = | 54.5 | nM | 7.26 |
| CHEMBL5185530 | — | IC50 | = | 108.5 | nM | 6.96 |
| CHEMBL5176948 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 3943.0 | nM | 5.40 |