Assay Detail
Functional
CHEMBL5111288
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Antiproliferative activity against human AGS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AGS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Potent STAT3 Inhibitor HP590 with Dual p-Tyr<sup>705</sup>/Ser<sup>727</sup> Inhibitory Activity for Gastric Cancer Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.50 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5182844 | — | — | 1 | 8.08 |
| CHEMBL5176948 | — | — | 1 | 8.06 |
| CHEMBL5176684 | — | — | 1 | 7.87 |
| CHEMBL5199234 | — | — | 1 | 7.67 |
| CHEMBL5171708 | — | — | 1 | 7.64 |
| CHEMBL5170615 | — | — | 1 | 7.63 |
| CHEMBL5189947 | — | — | 1 | 7.57 |
| CHEMBL5196490 | — | — | 1 | 7.57 |
| CHEMBL5182625 | — | — | 1 | 7.22 |
| CHEMBL5177332 | — | — | 1 | 7.17 |
| CHEMBL5185530 | — | — | 1 | 7.11 |
| CHEMBL64130 | NAPABUCASIN | 3.0 | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5182844 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL5176948 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL5176684 | — | IC50 | = | 13.5 | nM | 7.87 |
| CHEMBL5199234 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL5171708 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL5170615 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL5189947 | — | IC50 | = | 27.2 | nM | 7.57 |
| CHEMBL5196490 | — | IC50 | = | 27.1 | nM | 7.57 |
| CHEMBL5182625 | — | IC50 | = | 59.8 | nM | 7.22 |
| CHEMBL5177332 | — | IC50 | = | 67.6 | nM | 7.17 |
| CHEMBL5185530 | — | IC50 | = | 77.8 | nM | 7.11 |
| CHEMBL64130 | NAPABUCASIN | IC50 | = | 437.0 | nM | 6.36 |