Assay Detail
Functional
CHEMBL5111430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against MHV-nLuc infected in DBT cells assessed as effect on cell viability by LDH assay
30
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Murine hepatitis virus |
| Cell Type | Astrocytoma delayed brain tumor (DBT) cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.33 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297643 | APILIMOD | 2.0 | 2 | 7.80 |
| CHEMBL5174830 | — | — | 2 | 7.63 |
| CHEMBL4303292 | — | — | 2 | 7.39 |
| CHEMBL5171753 | — | — | 2 | 7.15 |
| CHEMBL5189479 | — | — | 2 | 7.13 |
| CHEMBL2178735 | — | — | 2 | 6.60 |
| CHEMBL5190524 | — | — | 2 | 6.31 |
| CHEMBL5188159 | — | — | 2 | 6.18 |
| CHEMBL5207387 | — | — | 2 | 6.15 |
| CHEMBL5190724 | — | — | 2 | 5.75 |
| CHEMBL5171207 | — | — | 2 | 5.72 |
| CHEMBL5200109 | — | — | 2 | 5.27 |
| CHEMBL5192827 | — | — | 2 | 5.09 |
| CHEMBL5202422 | — | — | 2 | 5.07 |
| CHEMBL5199026 | — | — | 2 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297643 | APILIMOD | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4297643 | APILIMOD | IC50 | = | 15.7 | nM | 7.80 |
| CHEMBL5174830 | — | IC50 | = | 23.44 | nM | 7.63 |
| CHEMBL5174830 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL4303292 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL4303292 | — | IC50 | = | 40.74 | nM | 7.39 |
| CHEMBL5171753 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL5171753 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5189479 | — | IC50 | = | 74.13 | nM | 7.13 |
| CHEMBL5189479 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL2178735 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2178735 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5190524 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL5190524 | — | IC50 | = | 489.78 | nM | 6.31 |
| CHEMBL5188159 | — | IC50 | = | 660.69 | nM | 6.18 |
| CHEMBL5188159 | — | IC50 | = | 666.0 | nM | 6.18 |
| CHEMBL5207387 | — | IC50 | = | 713.0 | nM | 6.15 |
| CHEMBL5207387 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL5190724 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5190724 | — | IC50 | = | 1778.28 | nM | 5.75 |
| CHEMBL5171207 | — | IC50 | = | 1920.0 | nM | 5.72 |
| CHEMBL5171207 | — | IC50 | = | 1905.46 | nM | 5.72 |
| CHEMBL5200109 | — | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL5200109 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL5192827 | — | IC50 | = | 8128.31 | nM | 5.09 |
| CHEMBL5192827 | — | IC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL5202422 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL5202422 | — | IC50 | = | 8470.0 | nM | 5.07 |
| CHEMBL5199026 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5199026 | — | IC50 | > | 10000.0 | nM | - |