Assay Detail
Binding
CHEMBL5111624
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length LIMK2 (330 to 632 residues) (unknown origin) expressed in HEK293T cells incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.86 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5169387 | — | — | 1 | 7.89 |
| CHEMBL2141887 | — | — | 1 | 7.77 |
| CHEMBL5181311 | — | — | 1 | 7.21 |
| CHEMBL5206269 | — | — | 1 | 7.19 |
| CHEMBL5190928 | — | — | 1 | 7.17 |
| CHEMBL5184302 | — | — | 1 | 7.06 |
| CHEMBL5184275 | — | — | 1 | 7.05 |
| CHEMBL4790618 | — | — | 1 | 7.04 |
| CHEMBL5179261 | — | — | 1 | 7.04 |
| CHEMBL5190028 | — | — | 1 | 6.93 |
| CHEMBL5202731 | — | — | 1 | 6.92 |
| CHEMBL5192852 | — | — | 1 | 6.79 |
| CHEMBL5184915 | — | — | 1 | 6.49 |
| CHEMBL5180888 | — | — | 1 | 6.36 |
| CHEMBL5180550 | — | — | 1 | 6.24 |
| CHEMBL5174511 | — | — | 1 | 4.62 |
| CHEMBL4779405 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5169387 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2141887 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL5181311 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5206269 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5190928 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5184302 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL5184275 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4790618 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL5179261 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL5190028 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5202731 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5192852 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL5184915 | — | IC50 | = | 323.0 | nM | 6.49 |
| CHEMBL5180888 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5180550 | — | IC50 | = | 573.0 | nM | 6.24 |
| CHEMBL5174511 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4779405 | — | IC50 | > | 25000.0 | nM | - |