Assay Detail

CHEMBL5111705

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Binding

Inhibition of LIMK2 (unknown origin)

ChEMBL ↗

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Target

LIM domain kinase 2 (CHEMBL5932) ↗

Open DB target context

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LIM domain kinase 2 (CHEMBL5932) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target LIM domain kinase 2

CHEMBL5932

Anchored from Assay target.

Protein identity LIM domain kinase 2

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

LIM domain kinase 2 (CHEMBL5932) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes.

Hanke T, Mathea S, Woortman J, Salah E, Berger BT, Tumber A, Kashima R, Hata A, Kuster B, Müller S, Knapp S.
J Med Chem (2022) 65 : 13264 -13287
PubMed 36136092 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.21	8.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3356433	LX-7101	1.0	1	8.80
CHEMBL3410036	—	—	1	7.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3356433	LX-7101	IC50	=	1.6	nM	8.80
CHEMBL3410036	—	IC50	=	24.0	nM	7.62