Assay Detail
Binding
CHEMBL5111870
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Binding affinity to recombinant PRC2 complex (unknown origin) incubated for 90 seconds by surface plasmon resonance assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 17 | 6.68 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3414621 | TAZEMETOSTAT | 4.0 | 1 | 8.07 |
| CHEMBL4532174 | — | — | 1 | 7.68 |
| CHEMBL5189365 | — | — | 1 | 7.41 |
| CHEMBL5176169 | — | — | 1 | 7.14 |
| CHEMBL5205080 | — | — | 1 | 7.12 |
| CHEMBL5192423 | — | — | 1 | 7.08 |
| CHEMBL5173660 | — | — | 1 | 7.01 |
| CHEMBL5186225 | — | — | 1 | 6.62 |
| CHEMBL5177261 | — | — | 1 | 6.55 |
| CHEMBL5174790 | — | — | 1 | 6.54 |
| CHEMBL5208164 | — | — | 1 | 6.39 |
| CHEMBL5200979 | — | — | 1 | 6.36 |
| CHEMBL5173482 | — | — | 1 | 6.30 |
| CHEMBL5177842 | — | — | 1 | 6.27 |
| CHEMBL5182624 | — | — | 1 | 6.02 |
| CHEMBL5197618 | — | — | 1 | 5.86 |
| CHEMBL5183275 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3414621 | TAZEMETOSTAT | Kd | = | 8.6 | nM | 8.07 |
| CHEMBL4532174 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL5189365 | — | Kd | = | 39.0 | nM | 7.41 |
| CHEMBL5176169 | — | Kd | = | 73.0 | nM | 7.14 |
| CHEMBL5205080 | — | Kd | = | 75.0 | nM | 7.12 |
| CHEMBL5192423 | — | Kd | = | 84.0 | nM | 7.08 |
| CHEMBL5173660 | — | Kd | = | 97.0 | nM | 7.01 |
| CHEMBL5186225 | — | Kd | = | 240.0 | nM | 6.62 |
| CHEMBL5177261 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL5174790 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL5208164 | — | Kd | = | 410.0 | nM | 6.39 |
| CHEMBL5200979 | — | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL5173482 | — | Kd | = | 500.0 | nM | 6.30 |
| CHEMBL5177842 | — | Kd | = | 540.0 | nM | 6.27 |
| CHEMBL5182624 | — | Kd | = | 960.0 | nM | 6.02 |
| CHEMBL5197618 | — | Kd | = | 1370.0 | nM | 5.86 |
| CHEMBL5183275 | — | Kd | = | 7700.0 | nM | 5.11 |