Assay Detail
Functional
CHEMBL5111873
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Antiproliferative activity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CCK-8 assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.63 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5189365 | — | — | 1 | 6.77 |
| CHEMBL5174790 | — | — | 1 | 6.32 |
| CHEMBL5173660 | — | — | 1 | 6.24 |
| CHEMBL5177842 | — | — | 1 | 6.20 |
| CHEMBL5187019 | — | — | 1 | 6.20 |
| CHEMBL5191470 | — | — | 1 | 6.19 |
| CHEMBL5184172 | — | — | 1 | 6.15 |
| CHEMBL5205080 | — | — | 1 | 6.13 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.07 |
| CHEMBL5182624 | — | — | 1 | 5.98 |
| CHEMBL5188854 | — | — | 1 | 5.97 |
| CHEMBL5192423 | — | — | 1 | 5.94 |
| CHEMBL5193584 | — | — | 1 | 5.83 |
| CHEMBL5200979 | — | — | 1 | 5.82 |
| CHEMBL5183275 | — | — | 1 | 5.51 |
| CHEMBL5197618 | — | — | 1 | 5.32 |
| CHEMBL5176169 | — | — | 1 | 5.29 |
| CHEMBL5186225 | — | — | 1 | 5.21 |
| CHEMBL5196140 | — | — | 1 | 5.15 |
| CHEMBL5208164 | — | — | 1 | 5.09 |
| CHEMBL4532174 | — | — | 1 | 4.95 |
| CHEMBL5177731 | — | — | 1 | 4.95 |
| CHEMBL5173482 | — | — | 1 | 4.84 |
| CHEMBL5177261 | — | — | 1 | 4.75 |
| CHEMBL5174084 | — | — | 1 | 4.73 |
| CHEMBL5171670 | — | — | 1 | 4.72 |
| CHEMBL5201866 | — | — | 1 | - |
| CHEMBL5192032 | — | — | 1 | - |
| CHEMBL5169646 | — | — | 1 | - |
| CHEMBL3414621 | TAZEMETOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5189365 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5174790 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5173660 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5177842 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5187019 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL5191470 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5184172 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5205080 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5182624 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL5188854 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL5192423 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5193584 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL5200979 | — | IC50 | = | 1530.0 | nM | 5.82 |
| CHEMBL5183275 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL5197618 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL5176169 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL5186225 | — | IC50 | = | 6180.0 | nM | 5.21 |
| CHEMBL5196140 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL5208164 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL4532174 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL5177731 | — | IC50 | = | 11210.0 | nM | 4.95 |
| CHEMBL5173482 | — | IC50 | = | 14550.0 | nM | 4.84 |
| CHEMBL5177261 | — | IC50 | = | 17660.0 | nM | 4.75 |
| CHEMBL5174084 | — | IC50 | = | 18550.0 | nM | 4.73 |
| CHEMBL5171670 | — | IC50 | = | 18830.0 | nM | 4.72 |
| CHEMBL5201866 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5192032 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5169646 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3414621 | TAZEMETOSTAT | IC50 | > | 20000.0 | nM | - |
| CHEMBL5178386 | — | IC50 | > | 20000.0 | nM | - |